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The principle endpoint was the proportion of patients achieving significant response in improvement of HS severity at 12 weeks utilizing the ghd australia network 7 layer HISCR measure. Final results for Period B are not presented.4The most common adverse events (AEs) (>10 percent of subjects in a treatment group) observed in PIONEER II with HUMIRA versus placebo were headache (12.9 percent versus 12.9 percent) and exacerbation of HS (4.3 % versus 12.9 %). Serious AEs in patients receiving HUMIRA included infection unknown source (n=1) and acute renal failure (n=1).4HUMIRA in conjunction with methotrexate is indicated for:dealing with moderate to severe, active arthritis in adult patients in the event the respond to disease modifying anti rheumatic drugs including methotrexate may be inadequate.the treating of severe, active and progressive rheumatoid arthritis symptoms symptoms in grown-ups not previously helped by methotrexate...
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