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The 2 main major metabolites usually do not have the symptoms of significant toxicity (and antimicrobial activity), and accordingly linezolid does not have to be altered for patients with renal impairment [21]. One of the most abundant minor metabolites PNU 173558, PNU 143131, PNU 142618 be the cause of approximately 3.3, 1.0 and 1.0% of dose, respectively. Patterns of metabolism are preserved across species [22].
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