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Pueden producir efectos adversos especficos, pero algunos efectos son comunes a todos los citotxicos, como la depresin inmunolgica y de la mdula sea. Adems, el uso concomitante de inmunosupresores aumenta la susceptibilidad a las infecciones. La fiebre asociada a neutropenia o inmunosupresin requiere tratamiento inmediato con antibiticos.Nusea y vmitos..